News & Events
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September 9, 2019 - September 10, 2019
Solutions to Drug Development Challenges Workshop: Utilizing Quantitative Approaches, Data Sharing, and Novel Biomarkers
Title Presenter Presentation Link Introduction Dr. John-Michael Sauer (C-Path) Keynote Address Dr. Joseph Scheeren (C-Path) Welcoming Remarks Dr. Janet Woodcock (US FDA) Session 2: Benefits of DDT progression to regulatory acceptance Moderators: Dr. Inish O’Doherty (C-Path) and Dr. Ameeta Parekh (US FDA) 2.1 A perspective on the history and evolution of drug development...... -
April 17, 2019 - April 18, 2019
2019 PSTC Japan Safety Biomarker Conference
Summary With the cooperation and support of RIKEN, NIHS, JSOT and JPMA, the Predictive Safety Testing Consortium (PSTC) of the Critical Path Institute hosted the 2nd PSTC Japan Safety Biomarker Conference from April 17-18, 2019 in Yokohama, Japan. The utilization of biomarkers in guiding drug development decisions through clinical trials and post marketing studies is...... -
October 30, 2018
Webinar Recording Available: Acetaminophen-Induced Liver Toxicity Mechanisms, Diagnosis and Treatment
Members of C-Path’s Predictive Safety Testing Consortium (PSTC) were among the featured facilitators and speakers of an educational webinar, sponsored and hosted by the Clinical and Translational Toxicology Specialty Section of the Society of Toxicology, on acetaminophen (APAP) induced liver toxicity. With a duration of 1 hour and 12 minutes, this Oct. 30, 2018 event...... -
June 6, 2017 - June 7, 2017
Drug-Induced Liver Injury (DILI) Conference XVII
Asymmetry of Drug Safety and Efficacy in Clinical Trials with DILI- Toward Quantitative Estimate of Net Benefit to Patients June 6, 2017 – June 7, 2017 College Park Marriott Hotel and Conference Center Paul Watkins, Mark Avigan, John-Michael Sauer, Arie Regev, Gyongyi Szabo, John Senior Drug-induced liver injury (DILI) is a major problem for drug...... -
May 26, 2016 - July 14, 2016
Current trends in BSEP inhibition and perturbation to bile acid homeostasis as mechanisms of drug-induced liver injury
The Critical Path Institute’s Predictive Safety Testing Consortium hosted a webinar series focused on BSEP inhibition and perturbation to bile acid homeostasis as mechanisms of drug-induced liver injury. Over the course of six two-hour webinars, scientists presented current data and research on clinical examples of BSEP inhibition and hepatotoxicity, in vivo tools for confirming perturbation......